{"id":16843,"date":"2023-09-21T12:39:58","date_gmt":"2023-09-21T10:39:58","guid":{"rendered":"https:\/\/mostakbalaldawaa.com\/?p=16843"},"modified":"2023-09-21T12:39:58","modified_gmt":"2023-09-21T10:39:58","slug":"%d8%a7%d9%84%d9%85%d9%81%d9%88%d8%b6%d9%8a%d8%a9-%d8%a7%d9%84%d8%a3%d9%88%d8%b1%d9%88%d8%a8%d9%8a%d8%a9-%d8%aa%d9%85%d9%86%d8%ad-%d8%a7%d9%84%d9%85%d9%88%d8%a7%d9%81%d9%82%d8%a9-%d8%b9%d9%84%d9%89","status":"publish","type":"post","link":"https:\/\/mostakbalaldawaa.com\/?p=16843","title":{"rendered":"\u0627\u0644\u0645\u0641\u0648\u0636\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u062a\u0645\u0646\u062d \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0639\u0642\u0627\u0631 \u00ab\u0623\u0648\u0631\u0633\u064a\u0631\u062f\u0648\u00bb \u0645\u0646 \u00ab\u0645\u064a\u0646\u0627\u0631\u064a\u0646\u064a\u00bb \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a"},"content":{"rendered":"

\u0645\u0646\u062d\u062a \u0627\u0644\u0645\u0641\u0648\u0636\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 (EC) \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0639\u0642\u0627\u0631 Orserdu (elacestrant) \u0627\u0644\u062a\u0627\u0628\u0639 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 Menarini Group \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER) \u0623\u0648 \u0633\u0644\u0628\u064a HER2 \u0623\u0648 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u062d\u0644\u064a\u064b\u0627 \u0623\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a (mBC).<\/h4>\n

\u062d\u0635\u0644 Orserdu \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0643\u0639\u0644\u0627\u062c \u0648\u062d\u064a\u062f \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u064a \u0627\u0644\u0646\u0633\u0627\u0621 \u0648\u0627\u0644\u0631\u062c\u0627\u0644 \u0628\u0639\u062f \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u0637\u0645\u062b \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0623\u0648\u0631\u0627\u0645 \u062a\u062d\u0645\u0644 \u0637\u0641\u0631\u0629 ESR1 \u0627\u0644\u0645\u0646\u0634\u0637\u0629.<\/h4>\n

\u064a\u062c\u0628 \u0623\u064a\u0636\u064b\u0627 \u0623\u0646 \u064a\u0643\u0648\u0646 \u0647\u0624\u0644\u0627\u0621 \u0627\u0644\u0645\u0631\u0636\u0649 \u0642\u062f \u062a\u0637\u0648\u0631\u0648\u0627 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u062e\u0637 \u0648\u0627\u062d\u062f \u0639\u0644\u0649 \u0627\u0644\u0623\u0642\u0644 \u0645\u0646 \u0639\u0644\u0627\u062c \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u0627\u0621 \u0645\u062b\u0644 \u0645\u062b\u0628\u0637 CDK 4\/6 \u0644\u064a\u0643\u0648\u0646\u0648\u0627 \u0645\u0624\u0647\u0644\u064a\u0646 \u0644\u062a\u0644\u0642\u064a Orserdu.<\/h4>\n

\u0648\u064a\u0623\u062a\u064a \u0642\u0631\u0627\u0631 \u0627\u0644\u0645\u0641\u0648\u0636\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0628\u0639\u062f \u0623\u0646 \u0642\u062f\u0645\u062a \u0644\u062c\u0646\u0629 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u0634\u0631\u064a (CHMP) \u0627\u0644\u062a\u0627\u0628\u0639\u0629 \u0644\u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 (EMA) \u0631\u0623\u064a\u064b\u0627 \u0625\u064a\u062c\u0627\u0628\u064a\u064b\u0627 \u0641\u064a \u064a\u0648\u0644\u064a\u0648 2023 \u0623\u0648\u0635\u062a \u0628\u0645\u0646\u062d \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c.<\/h4>\n

\u0648\u0627\u0633\u062a\u0646\u0627\u062f\u064b\u0627 \u0625\u0644\u0649 \u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629 \u0645\u0646 \u062a\u062c\u0631\u0628\u0629 EMERALD \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629\u060c \u0645\u0646\u062d\u062a \u0627\u0644\u0645\u0641\u0648\u0636\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 Orserdu \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0645\u0624\u0634\u0631.<\/h4>\n

\u0623\u0638\u0647\u0631\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0623\u0646 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 elacestrant \u064a\u0648\u0641\u0631 \u0628\u0642\u0627\u0621\u064b \u062e\u0627\u0644\u064a\u064b\u0627 \u0645\u0646 \u0627\u0644\u062a\u0642\u062f\u0645 (PFS) \u0630\u0648 \u062f\u0644\u0627\u0644\u0629 \u0625\u062d\u0635\u0627\u0626\u064a\u0629 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0642\u064a\u0627\u0633\u064a \u0644\u0644\u0631\u0639\u0627\u064a\u0629 \u0645\u0639 \u0639\u0644\u0627\u062c \u0648\u062d\u064a\u062f \u0644\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u0627\u0621 \u0645\u0639\u062a\u0645\u062f \u062d\u0633\u0628 \u062a\u0641\u0636\u064a\u0644\u0627\u062a \u0627\u0644\u0628\u0627\u062d\u062b.<\/h4>\n

\u0641\u064a \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0643\u0627\u0646\u062a \u0623\u0648\u0631\u0627\u0645\u0647\u0645 \u062a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0637\u0641\u0631\u0627\u062a ESR1\u060c \u0642\u062f\u0645 elacestrant \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0645\u0639\u062f\u0644 \u0627\u0644\u0628\u0642\u0627\u0621 \u0639\u0644\u0649 \u0642\u064a\u062f \u0627\u0644\u062d\u064a\u0627\u0629 \u0642\u062f\u0631\u0647 3.8 \u0634\u0647\u0631\u064b\u0627 \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0640 1.9 \u0634\u0647\u0631\u064b\u0627 \u0628\u0639\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0633\u062a\u062e\u062f\u0627\u0645 SOC.<\/h4>\n

\u0643\u0645\u0627 \u064a\u0642\u0644\u0644 Elacestrant \u0645\u0646 \u062a\u0637\u0648\u0631 \u0627\u0644\u0645\u0631\u0636 \u0623\u0648 \u062e\u0637\u0631 \u0627\u0644\u0648\u0641\u0627\u0629 \u0628\u0646\u0633\u0628\u0629 45% \u0645\u0642\u0627\u0631\u0646\u0629 \u0628\u0640SOC.<\/h4>\n

\u0648\u0642\u0627\u0644 \u0625\u0644\u0633\u064a\u0646 \u0628\u0627\u0631\u0643\u0631 \u0625\u0631\u062c\u0648\u0646\u060c \u0627\u0644\u0631\u0626\u064a\u0633 \u0627\u0644\u062a\u0646\u0641\u064a\u0630\u064a \u0644\u0645\u062c\u0645\u0648\u0639\u0629 \u0645\u064a\u0646\u0627\u0631\u064a\u0646\u064a: “\u0644\u0642\u062f \u0639\u0631\u0641\u0646\u0627 \u0645\u0646\u0630 \u0641\u062a\u0631\u0629 \u0637\u0648\u064a\u0644\u0629 \u0623\u0646 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a \u064a\u062d\u062a\u0627\u062c\u0648\u0646 \u0625\u0644\u0649 \u062e\u064a\u0627\u0631\u0627\u062a \u0641\u0639\u0627\u0644\u0629 \u0648\u0645\u0642\u0628\u0648\u0644\u0629 \u062a\u0639\u0627\u0644\u062c \u0645\u0631\u0636\u0647\u0645 \u0628\u064a\u0646\u0645\u0627 \u062a\u0645\u0643\u0646\u0647\u0645 \u0645\u0646 \u0627\u0644\u062a\u0631\u0643\u064a\u0632 \u0639\u0644\u0649 \u0627\u0644\u0623\u0634\u064a\u0627\u0621 \u0627\u0644\u062a\u064a \u062a\u0647\u0645\u0647\u0645.<\/h4>\n

“\u0646\u062d\u0646 \u0641\u062e\u0648\u0631\u0648\u0646 \u0628\u062a\u0642\u062f\u064a\u0645 \u0639\u0644\u0627\u062c \u062c\u062f\u064a\u062f \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u064a\u0648\u0641\u0631 \u0641\u0639\u0627\u0644\u064a\u0629 \u0641\u064a \u062d\u0628\u0629 \u0648\u0627\u062d\u062f\u0629 \u064a\u0648\u0645\u064a\u064b\u0627 \u0648\u064a\u0645\u062b\u0644 \u0623\u0648\u0644 \u0627\u0628\u062a\u0643\u0627\u0631 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0635\u0645\u0627\u0621 \u0645\u0646\u0630 \u0645\u0627 \u064a\u0642\u0631\u0628 \u0645\u0646 \u0639\u0642\u062f\u064a\u0646 \u0645\u0646 \u0627\u0644\u0632\u0645\u0646\u061b \u0643\u0645\u0627 \u0623\u0646\u0646\u0627 \u0645\u0645\u062a\u0646\u0648\u0646 \u0644\u0644\u063a\u0627\u064a\u0629 \u0644\u062f\u0639\u0645 \u0627\u0644\u0628\u0627\u062d\u062b\u064a\u0646 \u0641\u064a \u0639\u0644\u0645 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0648\u062c\u0645\u064a\u0639 \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u0634\u0627\u0631\u0643\u0648\u0627 \u0641\u064a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0627\u0644\u062a\u064a \u062c\u0639\u0644\u062a \u0625\u0646\u062c\u0627\u0632 \u0627\u0644\u064a\u0648\u0645 \u0645\u0645\u0643\u0646\u064b\u0627.<\/h4>\n

\u0648\u0642\u0639\u062a \u0634\u0631\u0643\u0629 Menarini Asia-Pacific \u0645\u0624\u062e\u0631\u064b\u0627 \u0635\u0641\u0642\u0629 \u0644\u062a\u0631\u062e\u064a\u0635 \u0634\u0631\u0643\u0629 Smyraf \u0627\u0644\u062a\u0627\u0628\u0639\u0629 \u0644\u0634\u0631\u0643\u0629 Astellas Pharma \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0641\u0627\u0635\u0644 \u0627\u0644\u0631\u0648\u0645\u0627\u062a\u0648\u064a\u062f\u064a.<\/h4>\n","protected":false},"excerpt":{"rendered":"

\u0645\u0646\u062d\u062a \u0627\u0644\u0645\u0641\u0648\u0636\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 (EC) \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0639\u0642\u0627\u0631 Orserdu (elacestrant) \u0627\u0644\u062a\u0627\u0628\u0639 \u0644\u0645\u062c\u0645\u0648\u0639\u0629 Menarini Group \u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u0636\u0649 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a \u0644\u0645\u0633\u062a\u0642\u0628\u0644\u0627\u062a \u0647\u0631\u0645\u0648\u0646 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 (ER) \u0623\u0648 \u0633\u0644\u0628\u064a HER2 \u0623\u0648 \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0645\u062d\u0644\u064a\u064b\u0627 \u0623\u0648 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0646\u0642\u064a\u0644\u064a (mBC). \u062d\u0635\u0644 Orserdu \u0639\u0644\u0649 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0643\u0639\u0644\u0627\u062c \u0648\u062d\u064a\u062f \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0641\u064a \u0627\u0644\u0646\u0633\u0627\u0621 \u0648\u0627\u0644\u0631\u062c\u0627\u0644 \u0628\u0639\u062f \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u0637\u0645\u062b \u0627\u0644\u0645\u0635\u0627\u0628\u064a\u0646 \u0628\u0623\u0648\u0631\u0627\u0645 \u062a\u062d\u0645\u0644 \u0637\u0641\u0631\u0629 ESR1 \u0627\u0644\u0645\u0646\u0634\u0637\u0629. …<\/p>\n","protected":false},"author":5,"featured_media":16844,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[106],"tags":[857,1034,1035,111],"class_list":["post-16843","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-106","tag-857","tag-1034","tag-1035","tag-111"],"_links":{"self":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts\/16843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=16843"}],"version-history":[{"count":1,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts\/16843\/revisions"}],"predecessor-version":[{"id":16845,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts\/16843\/revisions\/16845"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/media\/16844"}],"wp:attachment":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=16843"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=16843"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=16843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}