{"id":17608,"date":"2023-10-10T15:40:39","date_gmt":"2023-10-10T13:40:39","guid":{"rendered":"https:\/\/mostakbalaldawaa.com\/?p=17608"},"modified":"2023-10-10T15:40:39","modified_gmt":"2023-10-10T13:40:39","slug":"%d9%87%d9%8a%d8%a6%d8%a9-%d8%a7%d9%84%d8%af%d9%88%d8%a7%d8%a1-%d8%a7%d9%84%d8%a3%d9%85%d8%b1%d9%8a%d9%83%d9%8a%d8%a9-%d8%aa%d8%b1%d9%81%d8%b6-%d8%b9%d9%82%d8%a7%d8%b1-%d8%a3%d9%88%d9%86%d8%a8","status":"publish","type":"post","link":"https:\/\/mostakbalaldawaa.com\/?p=17608","title":{"rendered":"\u0647\u064a\u0626\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u062a\u0631\u0641\u0636 \u0639\u0642\u0627\u0631 \u00ab\u0623\u0648\u0646\u0628\u0627\u062a\u0631\u0648\u00bb \u0645\u0646 \u00ab\u0627\u0644\u0646\u064a\u0644\u0627\u0645\u00bb \u0644\u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628"},"content":{"rendered":"

\u0627\u0636\u0637\u0631\u062a \u0634\u0631\u0643\u0629 \u0627\u0644\u0646\u064a\u0644\u0627\u0645 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u062e\u0644\u064a \u0639\u0646 \u062e\u0637\u0637\u0647\u0627 \u0644\u0645\u0648\u0627\u0635\u0644\u0629 \u062a\u0648\u0633\u064a\u0639 \u0627\u0644\u0639\u0644\u0627\u0645\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u064a\u0629 \u0644\u0640 Onpattro (\u0628\u0627\u062a\u064a\u0633\u064a\u0631\u0627\u0646) \u0628\u0639\u062f \u0623\u0646 \u0623\u0635\u062f\u0631\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u062e\u0637\u0627\u0628 \u0627\u0644\u0631\u062f \u0627\u0644\u0643\u0627\u0645\u0644 (CRL).<\/h4>\n

\u062a\u0645 \u0625\u0635\u062f\u0627\u0631 CRL \u0628\u062e\u0635\u0648\u0635 \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0627\u0644\u062c\u062f\u064a\u062f (sNDA) \u0644\u0640 Onpattro \u0644\u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a \u0628\u0648\u0633\u0627\u0637\u0629 \u0627\u0644\u062a\u0631\u0627\u0646\u0633\u062b\u064a\u0631\u064a\u062a\u064a\u0646 (ATTR). \u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0631\u0633\u0627\u0644\u0629 \u0625\u0644\u0649 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0623\u062f\u0644\u0629 \u0643\u0627\u0641\u064a\u0629 \u0644\u0625\u062b\u0628\u0627\u062a \u0627\u0644\u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0623\u0648\u0646\u0628\u0627\u062a\u0631\u0648 \u0641\u064a \u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a ATTR \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u0628\u0631\u064a \u0623\u0648 \u0627\u0644\u0648\u0631\u0627\u062b\u064a\u060c \u0648\u0628\u0627\u0644\u062a\u0627\u0644\u064a\u060c “\u0644\u0627 \u064a\u0645\u0643\u0646 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u062f\u0648\u0627\u0621 \u0641\u064a \u0634\u0643\u0644\u0647 \u0627\u0644\u062d\u0627\u0644\u064a”.<\/h4>\n

\u0633\u0627\u0631\u0639 \u0627\u0644\u0646\u064a\u0644\u0627\u0645 \u0625\u0644\u0649 \u0625\u0636\u0627\u0641\u0629 \u0623\u0646 CRL \u0644\u0645 \u064a\u062d\u062f\u062f \u0623\u064a \u0645\u0634\u0627\u0643\u0644 \u062a\u062a\u0639\u0644\u0642 \u0628\u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0627\u0644\u0633\u0631\u064a\u0631\u064a\u0629 \u0623\u0648 \u062c\u0648\u062f\u0629 \u0627\u0644\u062f\u0648\u0627\u0621 \u0648\u062a\u0635\u0646\u064a\u0639\u0647.<\/h4>\n

\u064a\u0639\u062f CRL \u062a\u062d\u0648\u0644\u064b\u0627 \u0643\u0627\u0645\u0644\u0627\u064b \u0639\u0646 \u0627\u0644\u062a\u0648\u0635\u064a\u0629 \u0627\u0644\u0625\u064a\u062c\u0627\u0628\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u0644\u0642\u0627\u0647\u0627 Onpattro \u0645\u0646 \u0644\u062c\u0646\u0629 \u0627\u0644\u0644\u062c\u0646\u0629 \u0627\u0644\u0627\u0633\u062a\u0634\u0627\u0631\u064a\u0629 \u0644\u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 (AdCom) \u0641\u064a \u0633\u0628\u062a\u0645\u0628\u0631 \u0641\u064a\u0645\u0627 \u064a\u062a\u0639\u0644\u0642 \u0628\u062a\u0648\u0633\u064a\u0639 \u0627\u0644\u0645\u0644\u0635\u0642. \u0635\u0648\u062a\u062a \u0627\u0644\u0644\u062c\u0646\u0629 \u0628\u062a\u0633\u0639\u0629 \u0645\u0642\u0627\u0628\u0644 \u062b\u0644\u0627\u062b\u0629 \u0644\u0635\u0627\u0644\u062d \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0644\u062d\u0627\u0644\u0629 \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628.<\/h4>\n

Onpattro \u0647\u0648 \u0639\u0644\u0627\u062c \u0644\u062a\u062f\u0627\u062e\u0644 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a (RNAi) \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u064a\u0647 \u0644\u0623\u0648\u0644 \u0645\u0631\u0629 \u0645\u0646 \u0642\u0628\u0644 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a \u0627\u0644\u0648\u0631\u0627\u062b\u064a ATTR \u0641\u064a \u0639\u0627\u0645 2018. \u064a\u0642\u0644\u0644 Onpattro \u0645\u0646 \u0643\u0645\u064a\u0629 \u0627\u0644\u062a\u0631\u0627\u0646\u0633\u062b\u064a\u0631\u064a\u062a\u064a\u0646 \u0627\u0644\u0645\u062a\u062d\u0648\u0644\u0629 \u0623\u0648 \u0627\u0644\u0628\u0631\u064a\u0629 (TTR)\u060c \u0648\u0647\u0648 \u0628\u0631\u0648\u062a\u064a\u0646 \u0646\u0642\u0644 \u0645\u0648\u062c\u0648\u062f \u0641\u064a \u0627\u0644\u0643\u0628\u062f. \u0639\u0646 \u0637\u0631\u064a\u0642 \u0625\u0633\u0643\u0627\u062a TTR mRNA \u0627\u0644\u0645\u062a\u062d\u0648\u0644 \u0641\u064a \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a ATTR \u0627\u0644\u0648\u0631\u0627\u062b\u064a.<\/h4>\n

\u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a ATTR \u0647\u0648 \u062d\u0627\u0644\u0629 \u0646\u0627\u062f\u0631\u0629 \u0646\u0627\u062c\u0645\u0629 \u0639\u0646 \u062a\u0631\u0627\u0643\u0645 TTR\u060c \u0648\u062a\u062a\u0645\u064a\u0632 \u0628\u0648\u062c\u0648\u062f \u0643\u062a\u0644 \u0641\u064a \u0623\u0639\u0636\u0627\u0621 \u0627\u0644\u062c\u0633\u0645 \u0648\u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u0627\u0644\u0637\u0631\u0641\u064a\u0629. \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0623\u0639\u0635\u0627\u0628\u060c \u064a\u062d\u062f\u062b \u062a\u0631\u0627\u0643\u0645 TTR \u0641\u064a \u0627\u0644\u0623\u0639\u0635\u0627\u0628 \u0627\u0644\u0637\u0631\u0641\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0628\u0628 \u0623\u0639\u0631\u0627\u0636 \u0645\u062b\u0644 \u0627\u0644\u0648\u062e\u0632 \u0623\u0648 \u0627\u0644\u062a\u0646\u0645\u064a\u0644 \u0623\u0648 \u0627\u0644\u0623\u0644\u0645 \u0641\u064a \u0627\u0644\u064a\u062f\u064a\u0646 \u0648\u0627\u0644\u0642\u062f\u0645\u064a\u0646\u060c \u0628\u064a\u0646\u0645\u0627 \u0641\u064a \u062d\u0627\u0644\u0629 \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628\u060c \u062a\u062a\u0631\u0633\u0628 \u0643\u062a\u0644 TTR \u0647\u0630\u0647 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0642\u0644\u0628\u064a\u0629 \u0627\u0644\u0645\u0624\u062f\u064a\u0629 \u0625\u0644\u0649 \u0627\u0639\u062a\u0644\u0627\u0644 \u0627\u0644\u0623\u0639\u0635\u0627\u0628. \u0644\u0641\u0634\u0644 \u0627\u0644\u0642\u0644\u0628.<\/h4>\n","protected":false},"excerpt":{"rendered":"

\u0627\u0636\u0637\u0631\u062a \u0634\u0631\u0643\u0629 \u0627\u0644\u0646\u064a\u0644\u0627\u0645 \u0644\u0644\u0623\u062f\u0648\u064a\u0629 \u0625\u0644\u0649 \u0627\u0644\u062a\u062e\u0644\u064a \u0639\u0646 \u062e\u0637\u0637\u0647\u0627 \u0644\u0645\u0648\u0627\u0635\u0644\u0629 \u062a\u0648\u0633\u064a\u0639 \u0627\u0644\u0639\u0644\u0627\u0645\u0629 \u0627\u0644\u062a\u062c\u0627\u0631\u064a\u0629 \u0644\u0640 Onpattro (\u0628\u0627\u062a\u064a\u0633\u064a\u0631\u0627\u0646) \u0628\u0639\u062f \u0623\u0646 \u0623\u0635\u062f\u0631\u062a \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA) \u062e\u0637\u0627\u0628 \u0627\u0644\u0631\u062f \u0627\u0644\u0643\u0627\u0645\u0644 (CRL). \u062a\u0645 \u0625\u0635\u062f\u0627\u0631 CRL \u0628\u062e\u0635\u0648\u0635 \u0627\u0644\u062a\u0637\u0628\u064a\u0642 \u0627\u0644\u062f\u0648\u0627\u0626\u064a \u0627\u0644\u062c\u062f\u064a\u062f (sNDA) \u0644\u0640 Onpattro \u0644\u0639\u0644\u0627\u062c \u0627\u0639\u062a\u0644\u0627\u0644 \u0639\u0636\u0644\u0629 \u0627\u0644\u0642\u0644\u0628 \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u062f\u0627\u0621 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a \u0628\u0648\u0633\u0627\u0637\u0629 \u0627\u0644\u062a\u0631\u0627\u0646\u0633\u062b\u064a\u0631\u064a\u062a\u064a\u0646 (ATTR). \u0623\u0634\u0627\u0631\u062a \u0627\u0644\u0631\u0633\u0627\u0644\u0629 \u0625\u0644\u0649 \u0639\u062f\u0645 \u0648\u062c\u0648\u062f \u0623\u062f\u0644\u0629 …<\/p>\n","protected":false},"author":5,"featured_media":17609,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[106],"tags":[1438,1439,1440,111,284],"class_list":["post-17608","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-106","tag-1438","tag-1439","tag-1440","tag-111","tag-284"],"_links":{"self":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts\/17608","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=17608"}],"version-history":[{"count":1,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts\/17608\/revisions"}],"predecessor-version":[{"id":17610,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/posts\/17608\/revisions\/17610"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=\/wp\/v2\/media\/17609"}],"wp:attachment":[{"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=17608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=17608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mostakbalaldawaa.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=17608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}