<\/p>\n
\u064a\u062a\u0645 \u062a\u0645\u062f\u064a\u062f \u0627\u0644\u0645\u0644\u0635\u0642 \u0639\u0628\u0631 \u0646\u0648\u0639 \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a – \u0648\u0647\u0648 \u0637\u0631\u064a\u0642 \u064a\u0633\u062a\u062e\u062f\u0645 \u0639\u0646\u062f\u0645\u0627 \u062a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u062a\u063a\u064a\u064a\u0631 \u0643\u0628\u064a\u0631 \u0641\u064a \u062a\u0631\u062e\u064a\u0635 \u0627\u0644\u062a\u0633\u0648\u064a\u0642 \u0644\u062f\u0648\u0627\u0621 \u0645\u0639\u062a\u0645\u062f \u0641\u064a \u0623\u0648\u0631\u0648\u0628\u0627. \u0648\u062a\u0642\u062f\u0645\u062a \u0634\u0631\u0643\u0629 \u0628\u0627\u0641\u0627\u0631\u064a\u0627 \u0646\u0648\u0631\u062f\u064a\u0643 \u0628\u0637\u0644\u0628 \u0627\u0644\u062a\u063a\u064a\u064a\u0631 \u0627\u0644\u0634\u0647\u0631 \u0627\u0644\u0645\u0627\u0636\u064a.<\/p>\n
\u0623\u0648\u0635\u062a \u0644\u062c\u0646\u0629 \u0627\u0644\u0645\u0646\u062a\u062c\u0627\u062a \u0627\u0644\u0637\u0628\u064a\u0629 \u0644\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0628\u0634\u0631\u064a (CHMP) \u0628\u062a\u0648\u0633\u064a\u0639 \u062a\u0631\u062e\u064a\u0635 \u0627\u0644\u062a\u0633\u0648\u064a\u0642 \u0644\u064a\u0634\u0645\u0644 \u0627\u0644\u0645\u0631\u0627\u0647\u0642\u064a\u0646\u060c \u0648\u0647\u0648 \u0645\u0627 \u062f\u0639\u0645\u062a\u0647 \u0627\u0644\u0645\u0641\u0648\u0636\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0628\u0639\u062f \u0630\u0644\u0643\u060c \u0648\u0641\u0642\u064b\u0627 \u0644\u0628\u064a\u0627\u0646 \u0635\u062d\u0641\u064a \u0635\u062f\u0631 \u0641\u064a 19 \u0633\u0628\u062a\u0645\u0628\u0631\/\u0623\u064a\u0644\u0648\u0644.<\/p>\n
\u0648\u064a\u0639\u0646\u064a \u0627\u0644\u0642\u0631\u0627\u0631 \u0623\u0646\u0647\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0628\u0627\u0644\u063a\u064a\u0646\u060c \u064a\u0645\u0643\u0646 \u0627\u0644\u0622\u0646 \u0644\u0644\u0645\u0631\u0627\u0647\u0642\u064a\u0646 \u0641\u064a \u0623\u0648\u0631\u0648\u0628\u0627 \u0627\u0644\u0630\u064a\u0646 \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 12 \u064817 \u0639\u0627\u0645\u064b\u0627 \u062a\u0644\u0642\u064a \u0627\u0644\u0644\u0642\u0627\u062d.<\/p>\n
\u064a\u064f\u0637\u0644\u0642 \u0639\u0644\u0649 \u0644\u0642\u0627\u062d MVA-BN \u0627\u0644\u0630\u064a \u062a\u0646\u062a\u062c\u0647 \u0645\u0646\u0637\u0642\u0629 \u0628\u0627\u0641\u0627\u0631\u064a\u0627 \u0627\u0644\u0634\u0645\u0627\u0644\u064a\u0629 \u0627\u0633\u0645 Imvanex \u0641\u064a \u0623\u0648\u0631\u0648\u0628\u0627 \u0648\u0644\u0643\u0646\u0647 \u064a\u064f\u0639\u0631\u0641 \u0628\u0627\u0633\u0645 Jynneos \u0641\u064a \u062f\u0648\u0644 \u0645\u062b\u0644 \u0627\u0644\u0648\u0644\u0627\u064a\u0627\u062a \u0627\u0644\u0645\u062a\u062d\u062f\u0629 \u0648\u0633\u0646\u063a\u0627\u0641\u0648\u0631\u0629. \u0648\u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u062d\u0627\u0644\u064a\u060c \u062a\u0645\u062a \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0639\u0644\u0649 \u0627\u0644\u0644\u0642\u0627\u062d \u0644\u0644\u0628\u0627\u0644\u063a\u064a\u0646 \u0641\u0642\u0637 \u0645\u0646 \u0642\u0628\u0644 \u0625\u062f\u0627\u0631\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 (FDA).<\/p>\n
\u0648\u0623\u0643\u062f \u0645\u062a\u062d\u062f\u062b \u0628\u0627\u0633\u0645 \u0648\u0644\u0627\u064a\u0629 \u0628\u0627\u0641\u0627\u0631\u064a\u0627 \u0627\u0644\u0634\u0645\u0627\u0644\u064a\u0629 \u0623\u0646 \u0627\u0644\u0634\u0631\u0643\u0629 \u0644\u062f\u064a\u0647\u0627 “\u062e\u0637\u0637 \u0644\u062a\u0648\u0633\u064a\u0639 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0645\u0648\u0627\u0641\u0642\u0629 \u0647\u0630\u0647 \u0644\u062a\u0634\u0645\u0644 \u0628\u0644\u062f\u0627\u0646\u064b\u0627 \u0623\u062e\u0631\u0649 \u0639\u0627\u0644\u064a\u0629 \u0627\u0644\u0645\u062e\u0627\u0637\u0631”.<\/p>\n
\u0627\u0633\u062a\u0646\u062f \u0642\u0631\u0627\u0631 CHMP \u0625\u0644\u0649 \u0628\u064a\u0627\u0646\u0627\u062a \u0645\u0646 \u062a\u062c\u0631\u0628\u0629 \u0631\u0639\u062a\u0647\u0627 \u0627\u0644\u0645\u0639\u0627\u0647\u062f \u0627\u0644\u0648\u0637\u0646\u064a\u0629 \u0627\u0644\u0623\u0645\u0631\u064a\u0643\u064a\u0629 \u0644\u0644\u0635\u062d\u0629 (NIH) \u0634\u0645\u0644\u062a 315 \u0645\u0631\u0627\u0647\u0642\u064b\u0627 \u0648211 \u0628\u0627\u0644\u063a\u064b\u0627. \u0648\u0623\u0638\u0647\u0631\u062a \u0628\u064a\u0627\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u0631\u0628\u0629 \u0639\u062f\u0645 \u0646\u0642\u0635 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0627\u062a \u0627\u0644\u0645\u0646\u0627\u0639\u064a\u0629 \u0628\u064a\u0646 \u0627\u0644\u0641\u0626\u062a\u064a\u0646 \u0627\u0644\u0639\u0645\u0631\u064a\u062a\u064a\u0646 \u0628\u0639\u062f \u062c\u0631\u0639\u062a\u064a\u0646\u060c \u0625\u0644\u0649 \u062c\u0627\u0646\u0628 \u0645\u0644\u0641 \u062a\u0639\u0631\u064a\u0641 \u0623\u0645\u0627\u0646 \u0645\u0645\u0627\u062b\u0644.<\/p>\n
\u0648\u0642\u0627\u0644 \u0628\u0648\u0644 \u0634\u0627\u0628\u0644\u0646\u060c \u0627\u0644\u0631\u0626\u064a\u0633 \u0627\u0644\u062a\u0646\u0641\u064a\u0630\u064a \u0644\u0634\u0631\u0643\u0629 \u0628\u0627\u0641\u0627\u0631\u064a\u0627\u0646 \u0646\u0648\u0631\u062f\u064a\u0643: “\u064a\u0645\u062b\u0644 \u0647\u0630\u0627 \u0645\u0639\u0644\u0645\u0627 \u0647\u0627\u0645\u0627 \u0641\u064a \u062c\u0647\u0648\u062f\u0646\u0627 \u0644\u062c\u0639\u0644 \u0644\u0642\u0627\u062d\u0646\u0627 \u0645\u062a\u0627\u062d\u0627 \u0644\u062c\u0645\u064a\u0639 \u0627\u0644\u0633\u0643\u0627\u0646 \u0648\u0633\u064a\u0633\u0627\u0639\u062f \u0641\u064a \u062a\u062d\u0633\u064a\u0646 \u0627\u0644\u0648\u0635\u0648\u0644 \u0644\u0628\u0639\u0636 \u0627\u0644\u0623\u0641\u0631\u0627\u062f \u0627\u0644\u0623\u0643\u062b\u0631 \u0636\u0639\u0641\u0627 \u0648\u0627\u0644\u0645\u062a\u0623\u062b\u0631\u064a\u0646 \u0641\u064a \u0627\u0644\u063a\u0627\u0644\u0628 \u0628\u062a\u0641\u0634\u064a \u0627\u0644\u062c\u062f\u0631\u064a \u0627\u0644\u0645\u0633\u062a\u0645\u0631 \u0641\u064a \u0623\u0641\u0631\u064a\u0642\u064a\u0627”.<\/p>\n
\u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0637\u0644\u0628\u062a \u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0645\u0646 \u0645\u0646\u0637\u0642\u0629 \u0628\u0627\u0641\u0627\u0631\u064a\u0627 \u0627\u0644\u0634\u0645\u0627\u0644\u064a\u0629 \u062a\u0642\u062f\u064a\u0645 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0646\u0647\u0627\u0626\u064a\u0629 \u0644\u0644\u062f\u0631\u0627\u0633\u0629 \u0628\u062d\u0644\u0648\u0644 \u0645\u0627\u064a\u0648 \u0645\u0646 \u0627\u0644\u0639\u0627\u0645 \u0627\u0644\u0645\u0642\u0628\u0644 \u0644\u062a\u0642\u064a\u064a\u0645 \u0627\u0644\u0633\u0644\u0627\u0645\u0629 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0627\u0647\u0642\u064a\u0646 \u0628\u0634\u0643\u0644 \u0643\u0627\u0645\u0644\u060c \u0648\u0641\u0642\u064b\u0627 \u0644\u0628\u064a\u0627\u0646 \u0645\u0646\u0641\u0635\u0644 \u0635\u0627\u062f\u0631 \u0639\u0646 \u0627\u0644\u0648\u0643\u0627\u0644\u0629.<\/p>\n
<\/p>\n
\u064a\u0645\u0643\u0646 \u0623\u0646 \u064a\u0641\u062a\u062d \u0627\u0644\u0636\u0648\u0621 \u0627\u0644\u0623\u062e\u0636\u0631 \u0627\u0644\u0630\u064a \u0623\u0639\u0637\u062a\u0647 \u0648\u0643\u0627\u0644\u0629 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 \u0644\u0644\u0642\u0627\u062d \u0645\u0633\u0627\u0631\u0627\u062a \u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645\u0647 \u0644\u062f\u0649 \u0627\u0644\u0645\u0631\u0627\u0647\u0642\u064a\u0646 \u0641\u064a \u0623\u0641\u0631\u064a\u0642\u064a\u0627 \u0628\u0646\u0627\u0621\u064b \u0639\u0644\u0649 \u0627\u0644\u062a\u0623\u0647\u064a\u0644 \u0627\u0644\u0645\u0633\u0628\u0642 \u0644\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629. \u0641\u064a \u0627\u0644\u0623\u0633\u0628\u0648\u0639 \u0627\u0644\u0645\u0627\u0636\u064a\u060c \u062a\u0645\u062a \u0625\u0636\u0627\u0641\u0629 \u0639\u0642\u0627\u0631 \u0625\u0645\u0641\u0627\u0646\u064a\u0643\u0633 \u0625\u0644\u0649 \u0642\u0627\u0626\u0645\u0629 \u0627\u0644\u062a\u0623\u0647\u064a\u0644 \u0627\u0644\u0645\u0633\u0628\u0642 \u0644\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u0633\u0647\u0644 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 “\u062e\u0627\u0631\u062c \u0646\u0637\u0627\u0642 \u0627\u0644\u062a\u0633\u0645\u064a\u0629” \u0639\u0646\u062f \u0627\u0644\u0631\u0636\u0639 \u0648\u0627\u0644\u0646\u0633\u0627\u0621 \u0627\u0644\u062d\u0648\u0627\u0645\u0644 \u0648\u0627\u0644\u0623\u0634\u062e\u0627\u0635 \u0627\u0644\u0630\u064a\u0646 \u064a\u0639\u0627\u0646\u0648\u0646 \u0645\u0646 \u0636\u0639\u0641 \u0627\u0644\u0645\u0646\u0627\u0639\u0629\u060c \u0645\u0646 \u0628\u064a\u0646 \u0622\u062e\u0631\u064a\u0646\u060c \u0641\u064a \u0623\u0645\u0627\u0643\u0646 \u062a\u0641\u0634\u064a \u0627\u0644\u0645\u0631\u0636.<\/p>\n
<\/p>\n
\u062a\u0633\u062a\u0639\u062f \u0645\u0646\u0637\u0642\u0629 \u0628\u0627\u0641\u0627\u0631\u064a\u0627 \u0646\u0648\u0631\u062f\u064a\u0643 \u0644\u0625\u062c\u0631\u0627\u0621 \u062a\u062c\u0631\u0628\u0629 \u0633\u0631\u064a\u0631\u064a\u0629 \u0644\u0644\u0645\u0631\u062d\u0644\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 (NCT06549530) \u0644\u062a\u0642\u064a\u064a\u0645 \u0645\u0646\u0627\u0639\u0629 \u0648\u0633\u0644\u0627\u0645\u0629 MVA-BN \u0644\u062f\u0649 \u0627\u0644\u0623\u0637\u0641\u0627\u0644 \u0627\u0644\u0630\u064a\u0646 \u062a\u062a\u0631\u0627\u0648\u062d \u0623\u0639\u0645\u0627\u0631\u0647\u0645 \u0628\u064a\u0646 2 \u064812 \u0639\u0627\u0645\u064b\u0627. \u0648\u0642\u0627\u0644\u062a \u0627\u0644\u0634\u0631\u0643\u0629 \u0625\u0646\u0647\u0627 \u062a\u0647\u062f\u0641 \u0625\u0644\u0649 “\u062a\u0648\u0633\u064a\u0639 \u0646\u0637\u0627\u0642 \u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0627\u0644\u0644\u0642\u0627\u062d \u0644\u064a\u0634\u0645\u0644 \u0627\u0644\u0633\u0643\u0627\u0646 \u0627\u0644\u0623\u0635\u063a\u0631 \u0633\u0646\u0627”. \u0648\u0645\u0646 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0623\u0646 \u062a\u0628\u062f\u0623 \u0627\u0644\u062a\u062c\u0631\u0628\u0629\u060c \u0627\u0644\u0645\u0645\u0648\u0644\u0629 \u062c\u0632\u0626\u064a\u064b\u0627 \u0645\u0646 \u0642\u0628\u0644 \u0627\u0644\u062a\u062d\u0627\u0644\u0641 \u0645\u0646 \u0623\u062c\u0644 \u0627\u0628\u062a\u0643\u0627\u0631\u0627\u062a \u0627\u0644\u062a\u0623\u0647\u0628 \u0644\u0644\u0623\u0648\u0628\u0626\u0629 (CEPI)\u060c \u0627\u0644\u0634\u0647\u0631 \u0627\u0644\u0645\u0642\u0628\u0644.<\/p>\n
<\/p>\n
\u0648\u0645\u0646\u0630 \u0628\u062f\u0621 \u062a\u0641\u0634\u064a \u0627\u0644\u062c\u062f\u0631\u064a \u0641\u064a \u064a\u0646\u0627\u064a\u0631\/\u0643\u0627\u0646\u0648\u0646 \u0627\u0644\u062b\u0627\u0646\u064a\u060c \u0643\u0627\u0646 \u0647\u0646\u0627\u0643 \u0645\u0627 \u064a\u0632\u064a\u062f \u0642\u0644\u064a\u0644\u0627\u064b \u0639\u0646 25000 \u062d\u0627\u0644\u0629 \u0625\u0635\u0627\u0628\u0629 \u0648\u0623\u0643\u062b\u0631 \u0645\u0646 720 \u062d\u0627\u0644\u0629 \u0648\u0641\u0627\u0629 \u0641\u064a \u0623\u0641\u0631\u064a\u0642\u064a\u0627. \u0648\u0627\u0644\u062f\u0648\u0644\u0629 \u0627\u0644\u0623\u0643\u062b\u0631 \u062a\u0636\u0631\u0631\u0627 \u0641\u064a \u0627\u0644\u0648\u0642\u062a \u0627\u0644\u062d\u0627\u0644\u064a \u0647\u064a \u062c\u0645\u0647\u0648\u0631\u064a\u0629 \u0627\u0644\u0643\u0648\u0646\u063a\u0648 \u0627\u0644\u062f\u064a\u0645\u0642\u0631\u0627\u0637\u064a\u0629\u060c \u0648\u0641\u0642\u0627 \u0644\u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u0635\u062d\u0629 \u0627\u0644\u0639\u0627\u0644\u0645\u064a\u0629.<\/p>\n
<\/p>\n
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